The Bio-chemical Science pages of Glyn Wainwright, Publisher, Independent Reader of Research and Honorary Recording Engineer for Leeds Symphony Orchestra<
Anecdote: A diabetic clinician told me she had noticed that when patients had good control of their hba1c (an indicator of sugar-damage in blood ) their ‘cholesterol’ score also improved.
Every molecule of cholesterol in the body is known to be identical to every other.
The Good/Bad labeling of cholesterol is extremely unscientific and unhelpful, and that is a matter of scientific fact.
How were intelligent, well educated, medical professionals persuaded to popularise this ‘Good ‘ cholesterol versus ’Bad’ cholesterol idea?
The unscientific phrase ‘Bad Cholesterol’ is a misleading description of damage to the ’lipid transport system ‘, whose basic function was described by the Nobel Prize winners James E. Rothman, Randy W. Schekman and Thomas C. Südhof. (Awarded "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".
The lipid transport system is used by the body to deliver essential supplies of fat, cholesterol, and other fat-soluble nutrients.
The lipid transport system is able to repair and recycle, but can be progressively overwhelmed by the damage accumulated over several decades.
This damage to the lipid system is caused by oxidation and glycation: the result of excessive consumption of refined sugars (in particular High Fructose syrups).
It is not ‘bad cholesterol’ but sugar-damage to the proteins that make the lipids available to the organs of our body.
Unconsumed ‘damaged’ ldl in the blood is an indicator of trouble because the organs are being starved of vital fats cholesterol and fat-soluble nutrients.
‘Bad Medicine’ prevents the liver and all other organs from making essential cholesterol indirectly stop the supply of lipids to the blood.
Cholesterol lowering medications have a variety of very broad variety of adverse-effects, all attributable to organs being starved of fat, cholesterol and fat-soluble nutrients.
The ‘bad medicine’s do not tackle the cause of damage to the ldl - lipids supply.
The primary cause of this ldl damage is the oxidation and glycation of the ldl’s components.
The main dietary and lifestyle causes of ldl damage are over-consumption of refined sugars and inactivity.
The reactive sugars like fructose, found in manufactured corn syrups are particularly troublesome, because they directly attach to ldl-protein mechanisms causing a mal-function which starves the organs.
Important protective and anti-oxidant functions rely on Cholesterol and CoQ10 - both of which are reduced anti-cholesterol medications.
The unscientific use of the incorrect description ‘Bad Cholesterol’ has held back medicine for over 40 years and it is time to look at the evidence in more detail:-
“Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?” Seneff S, Wainwright G, and Mascitelli L Archives of Medical Science Vol. 7 Issue 1 p8-20 2011 doi: 10.5114/aoms.2011.20598
"Nutrition and Alzheimer’s disease: the detrimental role of a high carbohydrate diet" Seneff S., Wainwright G., and Mascitelli L. European Journal of Internal Medicine 2011, doi:10.1016/j.ejim.2010.12.0172011